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Submitted: 13 Mar 2022
Accepted: 22 May 2022
ePublished: 31 May 2022
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Immunopathol Persa. Inpress.
doi: 10.34172/ipp.2022.31400
  Abstract View: 906

Original

The effects of licorice mucoadhesive patches on the results of nasopharyngeal swab real-time polymerase chain reaction test of SARS-CoV-2; a randomized triple-blind placebo-controlled clinical trial

Morteza Pourahmad 1 ORCID logo, Kiana Shahzamani 2 ORCID logo, Fatemeh Nikokar 3 ORCID logo, Mohsen Saniei 4 ORCID logo, Matin Saniei 5 ORCID logo, Rasool Soltani 6,7* ORCID logo

1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Exir Danesh Asia Pharmaceutical Company, Isfahan, Iran
5 Department of Chemistry, Islamic Azad University of Khorasgan, Isfahan, Iran
6 Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Practice, Isfahan University of Medical Sciences, Isfahan, Iran
7 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Correspondence to Rasool Soltani, Email: , Email: soltani@pharm.mui.ac.ir

Abstract

Introduction: Glycyrrhizin (Licorice) is believed to have antiviral action against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Objectives: This study aimed to evaluate the effectiveness of oral mucoadhesive patches containing licorice extract in the eradication of this novel coronavirus in the nasopharyngeal secretions of the patients.

Patients and Methods: In this triple-blind randomized clinical trial, 125 patients with positive real-time PCR (polymerase chain reaction) for SARS-CoV-2 and in stages 0 and/or 1 of COVID-19 were studied in two separate groups, including interventional and placebo, in which they used Aftogel (licorice extract) and placebo patches, respectively. At the end of the study, the results of PCR test in aforementioned groups were assessed and compared.

Results: Following the application of Aftogel, real-time PCR converted to negative in 53.97% of patients which was significantly higher than that of the placebo groups. (27.40%, P=0.003).

Conclusion: It seems that Aftogel mucoadhesive patch is effective in the eradication of SARS-CoV-2, which has colonized the nasopharyngeal area. Hence, this drug product has the potential for evaluation as a prophylactic agent against COVID-19.

Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20181208041886N2; https://fa.irct.ir/trial/51774, ethical code; IR.MUI.MED.REC.1399.520).


Citation: Pourahmad M, Shahzamani K, Nikokar F, Saniei M, Saniei M, Soltani R. The effects of licorice mucoadhesive patches on the results of nasopharyngeal swab real-time polymerase chain reaction test of SARSCoV-2; a randomized triple-blind placebocontrolled clinical trial. Immunopathol Persa. 2022;x(x):e31400. DOI:10.34172/ ipp.2022.31400.
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