Nickan Research Institute Immunopathologia Persa 2423-8015 7 2 2021 07 01 The effect of hemoperfusion on the recovery of COVID-19 in hospitalized patients; case series and review study e13 e13 10.34172/ipp.2021.13 EN Sepideh Hajian https://orcid.org/0000-0001-5404-2765 Nafiseh Rastgoo https://orcid.org/0000-0003-3900-9291 Journal Article 10.34172/ipp.2021.13 2020 05 31 2020 07 29 Hemoperfusion is an effective modality in removing certain toxins from the blood, especially those that bind to proteins in the body. Hemoperfusion has shown a therapeutic effect on COVID-19 patients. In this case series, we report four patients without effective results following the use of hemoperfusion on the recovery of COVID-19 patients. This study is a case series which carried out on four patients referred to COVID-19 ward of Velayat hospital in Qazvin, Iran. The mean age of the COVID-19 patients was 52.75 ± 18 years. The mean stay at the hospital was 21.5 ± 15.15 days. This study showed that hemoperfusion cannot show a significant therapeutic effect on COVID-19.