Nickan Research Institute Immunopathologia Persa 2423-8015 8 2 2022 07 01 The soluble major histocompatibility complex class I chain-related gene A (sMICA) as an early biomarker for diagnosing acute myocardial infarction e29325 e29325 10.34172/ipp.2022.29325 EN Kambiz Masoumi https://orcid.org/0000-0001-7234-5671 Ali Khavanin https://orcid.org/0000-0002-8606-4923 Meisam Moezzi https://orcid.org/0000-0001-7794-2598 Habib Heybar https://orcid.org/0000-0002-9204-8698 Nastaran Ranjbari https://orcid.org/0000-0001-6488-5256 Nader Masoumi https://orcid.org/0000-0003-0208-9646 Mehdi Mokhtari https://orcid.org/0000-0002-4022-7440 Journal Article 10.34172/ipp.2022.29325 2021 10 29 2021 12 10 Introduction: It is necessary to identify tests that have high diagnostic power in the early hours of acute myocardial infarction. Objectives: In this study, we investigated the major histocompatibility complex class I chain-related molecule A (MICA) in the serum of patients with myocardial infarction (MI). Patients and Methods: In this study, 65 patients with MI were studied. Creatine phosphokinase-MB (CPK-MB), troponin I, and MICA biomarkers were measured at different times after hospitalization (0, 3, 6, 9, 12 and, 24 hours). These biomarkers were evaluated at different times after chest pain (0 to 3, 3 to 6, and more than 6 hours). Results: Serum MICA biomarker increased significantly from admission to the hospital until 3 hours. Later on, it decreased until 24 hours. However, CPK-MB biomarkers as well as troponin I, change from admission up to 24 hours. Regarding diagnostic power, it was found that the diagnostic power of MICA is high in the early hours which indicates the high diagnostic power of the test. Conclusion: The diagnostic value of MICA is significant in the early hours after MI. Therefore, due to the high accuracy of MICA in diagnosing MI, it should be used as a diagnostic test along with other tests to confirm MI in the early hours.