Nickan Research Institute Immunopathologia Persa 2423-8015 8 2 2022 07 01 Could inadvertent intravenous injection of COVID-19 vaccines cause severe adverse events? e31392 e31392 10.34172/ipp.2022.31392 EN Zohreh Tajabadi https://orcid.org/0000-0002-9854-7260 Seyed Amir Ahmad Safavi-Naini https://orcid.org/0000-0001-9295-9283 Bharat Kwatra https://orcid.org/0000-0002-7927-9715 Ali Safavi-Naini https://orcid.org/0000-0001-5686-1094 Journal Article 10.34172/ipp.2022.31392 2022 02 26 2022 04 06 The emergence and rapid spread of COVID-19 led to the development of novel vaccines to fight against the disease. Although COVID-19 vaccines are the major key to controlling the disease and have a good safety profile, they may be associated with some adverse events. Recently, a few studies noted that inadvertent incorrect injection of COVID-19 vaccines may lead to the development of serious adverse events. Herein, we report a case of inadvertent intravenous COVID-19 vaccine injection who developed severe anaphylactic shock following receiving the COVID-19 vaccine. Proper vaccine injection technique training may help to reduce the risk of developing adverse events and improve vaccine safety and efficacy.