Nickan Research Institute Immunopathologia Persa 2423-8015 12 1 2026 01 01 Frequency of treated hypothyroidism and effect on disease complications in COVID-19 patients in Razi Hospital of Ahvaz e40562 e40562 10.34172/ipp.2023.40562 EN Mona Hoseini https://orcid.org/0009-0008-0890-5556 Leila Moradi https://orcid.org/0000-0002-3317-1119 Hajieh Bibi Shahbazian https://orcid.org/0000-0002-9265-4022 Ferdos Zaman https://orcid.org/0000-0001-8183-387X Fatemeh Amiri https://orcid.org/0000-0003-4669-3749 Journal Article 10.34172/ipp.2023.40562 2023 06 08 2025 04 02 Introduction: COVID-19 infection (SARS-CoV-2) is associated with high morbidity and mortality rates, and worse outcomes have been reported for various morbidities. The impact of pre-existing hypothyroidism on COVID-19 outcomes is unclear. Objectives: This study aimed to evaluate the frequency of treated hypothyroidism and its effect on disease complications in COVID-19 patients in Razi hospital of Ahvaz. Patients and Methods: This cross-sectional study was conducted on patients with a laboratory and computed tomography (CT) confirmed COVID-19 diagnosis between August 2021 and December 2021 in Razi hospital in Ahvaz. The medical records of all patients were reviewed, and patient’s characteristics and outcomes related to COVID-19, including severe disease, hospitalization in intensive care unit (ICU), need for mechanical or invasive ventilation, and all-cause mortality, was collected. The presence of hypothyroidism was identified based on the patient’s medical history in the medical record. Results: Of 850 patients with COVID-19 positive, 59 patients (6.9%) had pre-existing hypothyroidism and received thyroid hormone replacement therapy. Hypothyroidism was not associated with increased risk of ICU admission (odds ratio [OR]: 0.447; 95% CI: 0.216-0.925, P=0.030), severe disease (OR: 1.237; 95% CI: 0.688-2.223, P=0.447) mechanical ventilation (OR: 1.785; 95% CI: 0.894-3.562; P=0.064) and death (OR: 0.997; 95% CI: 0.478-2.080; P=0.993). Conclusion: Our study showed that underlying hypothyroidism does not lead to worse outcomes and complications in patients with COVID-19. It suggests that hypothyroidism is not associated with a worse prognosis and should not be considered among the comorbidities that indicate a risk factor for COVID-19 severity and its complication.