Nickan Research Institute Immunopathologia Persa 2423-8015 12 1 2026 01 01 Treatment outcomes of total laryngectomy followed by localized radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma; a retrospective study e43936 e43936 10.34172/ipp.2025.43936 EN Ahmed Nabil Elsamanody https://orcid.org/0000-0001-6294-0565 Ahmed Seleim Mohammed Abdelfattah Eltawy Ahmed Seddik Abdelglil Mohammed Sherif Azzam https://orcid.org/0009-0001-2037-7345 Eslam Mohamed M. Ibrahim https://orcid.org/0009-0000-8500-9845 Mohamed Abdelfattah Mohamed Abd El-Rahman Alkenawy Ahmed Seif Elnasr Sedeek Mahmoud Mohamed Aboumandour Fouda https://orcid.org/0009-0006-7603-6474 Sameh Zayed https://orcid.org/0009-0004-6509-210X Ashraf Y. Hegab https://orcid.org/0009-0007-8282-4159 Hashem Bark A. Abood https://orcid.org/0009-0002-9955-550X Tamer A.A. Samih https://orcid.org/0000-0003-2672-4245 Hasan A. Soltan https://orcid.org/0000-0002-8436-0921 Journal Article 10.34172/ipp.2025.43936 2025 05 31 2025 08 23 Introduction: Locally advanced laryngeal squamous cell carcinoma often requires aggressive treatment. Total laryngectomy followed by radiotherapy remains a standard approach for achieving local control and improving survival when organ preservation is not feasible. Objectives: To evaluate the morbidity and mortality outcomes of patients with locally advanced laryngeal cancer (LC) managed with total laryngectomy followed by postoperative radiotherapy (TLPR) at a tertiary hospital in Egypt. Patients and Methods: This retrospective study included patients with a pathological diagnosis of T3 or T4 locally advanced LC treated with TLPR between 2017 and 2021, with a follow-up period of 33 months. Clinical and demographic variables, including age, gender, smoking status, tumor sub-site, TNM (tumor, node, metastasis) classification, clinical staging, pathological features, treatment modality, preoperative tracheostomy, postoperative fistula, and associated comorbidities, were collected and analyzed for their relationship to prognosis. Results: A total of 84 patients were included in the study, with a mean age of 52.93 years (range: 26–82 years) and a male-to-female ratio of 68% to 32%. Among the patients, 45.2% achieved complete response, 28.5% had partial response, 16.8% experienced stable disease, and 9.5% showed disease progression. Frequent relapse occurred in 22 patients. The mean overall survival was 57.29 ± 62.14 weeks (range: 8–242 weeks), while the mean progression-free survival was 26.81 ± 40.92 weeks (range: 6–225 weeks). Conclusion: Postoperative radiotherapy following total laryngectomy is an effective strategy for achieving better disease control and long-term survival in patients with locally advanced laryngeal squamous cell carcinoma.