Nickan Research Institute Immunopathologia Persa 2423-8015 6 1 2020 01 01 Predictive value of platelet indices in children with idiopathic nephrotic syndrome e04 e04 10.15171/ipp.2020.04 EN Azar Nickavar https://orcid.org/0000-0003-0740-0667 Sahar Sadr Moharerpour https://orcid.org/0000-0002-9083-1822 Ehsan Abiry https://orcid.org/0000-0003-4621-8358 Journal Article 10.15171/ipp.2020.04 2019 08 15 2019 11 02 Introduction: Different biomarkers have been investigated for prognosis of patients with nephrotic syndrome. Qualitative and quantitative changes have been reported in platelets in these patients. Objectives: The aim of this study was to identify platelet abnormalities and their prognostic value of steroid response in children with idiopathic nephrotic syndrome. Patients and Methods: Platelet counts and indices (mean platelet volume [MPV], platelet distribution width [PDW] and platelet larger cell ratio [PLCR]) were evaluated and compared in 122 children with active nephrotic syndrome (64%; steroid resistant and 36%; steroid sensitive). Results: Mean age at diagnosis was 55 months (6 to169 months), and males outnumbered females (1.7/1). Steroid resistant patients had significantly higher platelet counts and lower PLCR, compared to steroid sensitive group. Regarding area under the ROC curve, low MPV, high PDW and low PLCR showed relatively acceptable correlation with steroid resistance. Conclusion: Increased platelet counts in addition to low PLCR are the suggestive indicators of steroid resistance in children with idiopathic nephrotic syndrome.